hmga2 pathology outlines

HMGA2 protein expression correlates with lymph node metastasis and increased tumor grade in pancreatic ductal adenocarcinoma. When positive, a diagnosis of benign adipose lesion can be made with confidence since well-differentiated liposarcomas have never been described in the tracheobronchial tree. In contrast, the dysregulation of HMGA2 might cause a malignant phenotype when coupled with MDM2 amplification, as suggested by a study showing that the expression of MDM2 or CDK4 allowed human diploid fibroblast to by-pass HMGA2-induced proliferation arrest. Mansoori B, Mohammadi A, Ditzel HJ, Duijf PHG, Khaze V, Gjerstorff MF, Baradaran B. University of Southern California and Children’s Hospital Los Angeles are seeking an M.D., M.D. Thank you for joining our Facebook page. 94 talking about this. Coexpression of HMGA1 and HMGA2 is found in 86% of adenocarcinomas, 0% of reactive atypias, and 8% of adenomas. AKT pathway; HMGA2; Leiomyoma; angiogenesis; xenograft. Diagnostic difficulty and patient management are further complicated by a lack of studies and unknown cause of … HMGA2 (high mobility group AT-hook 2) HMGA2, the High Mobility Group A2 gene, is a non-histone and architectural transcription factor. Galindo LJ, Hernández-Beeftink T, Salas A, Jung Y, Reyes R, de Oca FM, Hernández M, Almeida TA. HM G proteins (HMGs) function as architectural factors and are … 103 talking about this. 2003 Mar 15;63(6):1351-8. PMID: 12649198, Van Dorpe J, Dal Cin P, Weremowicz S, Van Leuven F, de Wever I, Van den Berghe H, Fletcher CD, Sciot R. Translocation of the HMGI-C ( HMGA2) gene in a benign mesenchymoma (chondrolipoangioma). Results: HMGA2, the High Mobility Group A2 gene, plays a very important role in fetal development and carcinogenesis. PMID: 10686944, 1996 - 2021 Humpath.com - Human pathology Of all 178 leiomyomas examined, 74.7%(133/178) of uterine leiomyomas had MED12 mutations. McCluggage WG, Connolly L, McBride HA. Thank you for joining our Facebook page. HMGA2 is positive in 14% of reactive atypias, 42% of adenomas, and 86% of adenocarcinomas. Mod Pathol. 2014 Sep;102(3):621-9. doi: 10.1016/j.fertnstert.2014.06.050. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. 2017 Dec 15;77(24):6891-6901. doi: 10.1158/0008-5472.CAN-17-1744. 30100 Telegraph Road, Suite 408, Bingham Farms, Michigan 48025 (USA) Genes (Basel). PMID: 20551826, HMGA2: A Potential Biomarker Complement to P53 for Detection of Early-stage High-grade Papillary Serous Carcinoma in Fallopian Tubes. (Fusion of RDC1 with HMGA2 in lipomas). Genomics of uterine leiomyomas: insights from high-throughput sequencing. 8600 Rockville Pike Please enable it to take advantage of the complete set of features! 1999 Jul 15;112(2):156-60. Contact | Design: Overexpression of HMGA2 in MM and LM cell lines resulted in increased secretion of angiogenesis-associated factors. Moreover, some tumors with 12q rearrangements retain the full coding region of HMGA2, suggesting a nondependence of the HMGA2 oncogenic potential on the nature of the transcript. P01 HD057877/HD/NICHD NIH HHS/United States, NCI CPTC Antibody Characterization Program. PMID: 18828159, Italiano A, Bianchini L, Keslair F, Bonnafous S, Cardot-Leccia N, Coindre JM, Dumollard JM, Hofman P, Leroux A, Mainguené C, Peyrottes I, Ranchere-Vince D, Terrier P, Tran A, Gual P, Pedeutour F. HMGA2 is the partner of MDM2 in well-differentiated and dedifferentiated liposarcomas whereas CDK4 belongs to a distinct inconsistent amplicon. Clipboard, Search History, and several other advanced features are temporarily unavailable. Angiogenic factors and receptors were significantly upregulated at mRNA and protein levels in HMGA2-LM. The observation that the tumors developed in HMGA2 transgenic mice were always benign raises the question of the role of HMGA2 in malignancy. HMGA2-LM have a high vasculature density, which likely contributes to tumor growth and disease burden of this leiomyoma subtype. 107 talking about this. CALIFORNIA, LOS ANGELES (USA). Cancer Genet Cytogenet. MIM.600698 12q14-q15 HGNC:5009 Entrez:8091, Definition: The high mobility group A2 (HMGA2) protein is an architectural transcription factor that has recently been implicated in the development and progression of malignant tumors. The reason may be that HMGA2 promotes epithelial-mesenchymal transition (EMT) and the acquisition of tumor … PLAG1 and HMGA2 rearrangements are the most common genetic events in CA ex-PA regardless of the histologic subtype. PMID: 9205100, Kazmierczak B, Dal Cin P, Sciot R, Van den Berghe H, Bullerdiek J. Wei JJ, Wu J, Luan C, Yeldandi A, Lee P, Keh P, Liu J. PMID: 14614053, Pentimalli F, Dentice M, Fedele M, Pierantoni GM, Cito L, Pallante P, Santoro M, Viglietto G, Dal Cin P, Fusco A. Suppression of HMGA2 protein synthesis could be a tool for the therapy of well differentiated liposarcomas overexpressing HMGA2. Epub 2018 Jul 13. 76 talking about this. 2020 Dec 19;12(12):3839. doi: 10.3390/cancers12123839. We describe a case of a 44-year-old woman with locally advanced aggressive angiomyxoma with a novel translocation high-mobility group AT-hook 2-yes-associated protein 1 (HMGA2-YAP1) fusion, implying … In five CA ex‐PAs, HMGA2 showed weak‐to‐strong multifocal staining within the carcinomatous component, and strong diffuse HMGA2 expression in the residual PA. Mod Pathol. (4)Pathology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, USA. 2014 Mar-Apr;20(2):194-216. doi: 10.1093/humupd/dmt042. 2008 Aug 29. RNA-sequencing revealed an HMGA2-WIF1 fusion gene in an ER-positive AME lacking HRAS, PIK3CA and AKT1 somatic mutations. Thank you for joining our Facebook page. Published by Elsevier Inc. All rights reserved. HMG proteins (HMGs) function as architectural factors and are essential components of the enhancesome. The degradation of p53 is mediated by murine double minute 2 (MDM2) in a proteasome‐dependent manner. Hamartomas often have the t(3;12)(q27–28;q14–15) translocation, which results in gene fusion of the high-mobility group protein gene HMGA2 and the LPP gene. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Secreted factors promoted human umbilical vein endothelial cell (HUVEC) migration, tube formation, and wound healing. 2003 Nov;16(11):1132-40. Epub 2014 Jan 3. See : HMGs / HMGAs. Although CDK4 certainly plays an important role in a majority of cases, our results favor MDM2-HMGA2 instead of MDM2-CDK4 as the crucial couple of genes in WDLPS/DDLPS pathogenesis. These findings strongly suggest that MED12 mutations and HMGA2 overexpression are independent genetic events that occur in leiomyomas, and they may act differently in the tumorigenesis of uterine leiomyomas. Objective: The main outcome measures include vessel density in leiomyomas with HMGA2 (HMGA2-LM) or MED12 (MED12-LM) alteration; angiogenic factor expression in primary leiomyoma and in vitro cell line model; and vessel formation in leiomyoma cells with HMGA2 overexpression in vitro and in vivo. PMID: 19898227, Hristov AC, Cope L, Reyes MD, Singh M, Iacobuzio-Donahue C, Maitra A, Resar LM. p53 and β-catenin expression seems not to provide additional value for discriminating adenocarcinoma from reactive atypia or adenoma. However, the mechanism of HMGA2 regulation remains largely uncharacterized. HMGA2 immunostaining is an affordable and straightforward technique for accurate description of biopsies containing adipose cells. HMGA2 and high-grade serous ovarian carcinoma. The expression of HMGA2 in adult tissues is commonly associated with both malignant and benign tumor formation, as well as certain characteristic cancer-promoting mutations. PathologyOutlines.com, free, updated outline surgical pathology clinical pathology pathologist jobs, conferences, fellowships, books PMID: 21532495, HMGA2 is a sensitive but not specific immunohistochemical marker of vulvovaginal aggressive angiomyxoma. Wu X, Serna VA, Thomas J, Qiang W, Blumenfeld ML, Kurita T. Cancer Res. In lipomas, the preferential clustering of HMGA2 breakpoints in the third intron results in the replacement of the acidic C-terminal domain by a variety of ectopic sequences. Bertsch E, Qiang W, Zhang Q, Espona-Fiedler M, Druschitz S, Liu Y, Mittal K, Kong B, Kurita T, Wei JJ. Accessibility Here, we demonstrate that HMGA2 can be … RSS 2.0, aggressive angiomyxoma of the lower genital tract (33%) (, HMGA2-associated inflammatory myofibroblastic tumor (IMT) (, HMGA2/RDC1 fusion protein expression in lipomas as the result of chromosome aberrations involving 2q35-37 and 12q13-15. Wu J(1), Wei JJ. PMID: 18843278, Persson F, Andrén Y, Winnes M, Wedell B, Nordkvist A, Gudnadottir G, Dahlenfors R, Sjögren H, Mark J, Stenman G. High-resolution genomic profiling of adenomas and carcinomas of the salivary glands reveals amplification, rearrangement, and fusion of HMGA2. Thank you for joining our Facebook page. 2008 Sep 30. 2021 Feb 13;12(2):269. doi: 10.3390/genes12020269. Copyright © 2020 American Society for Reproductive Medicine. Some authors have proposed that the truncation of HMGA2 followed or not by the addition of ectopic sequences might be the critical steps in HMGA2 oncogenicity. HMGA2 as a Critical Regulator in Cancer Development. Amplification of 5′-UTR and exons 1–3 (P=0.08) and 3′-UTR (P=0.01) of HMGA2 were associated with longer recurrence-free survival. Histological assessment does not always predict tumour behaviour, hindering determination of the clinical course and management. Hum Reprod Update. (18843278), HMGA2 was identified as one of target genes of the let-7 family of miRNAs and has been found to be suppressed by let-7 in vitro. To study the role of HMGA2 in promoting angiogenesis in uterine leiomyoma (LM). Cancer Genet Cytogenet. Main outcome measures: (20551826), HMGA2 protein expression correlates with lymph node metastasis and increased tumor grade in pancreatic ductal adenocarcinoma. Virchows Arch. Zakharov V, Ren B, Ryan C, Cao W. Histopathology. PMID: 15036898, Dahlen A, Mertens F, Rydholm A, Brosjo O, Wejde J, Mandahl N, Panagopoulos I. Fusion, disruption, and expression of HMGA2 in bone and soft tissue chondromas. PMID: 16990720, Dal Cin P, Thomas A, Weremowicz S. An intragenic rearrangement of HMGA2 is not necessary for lipoma formation. Thank you for joining our Facebook page.  lipomas, HMGA2 is a sensitive but not specific immunohistochemical marker of vulvovaginal aggressive angiomyxoma. Thank you for joining our Facebook page. (23530587), Diagnostic value of HMGAs, p53 and β-catenin in discriminating adenocarcinoma from adenoma or reactive atypia in ampulla and common bile duct biopsies. National Library of Medicine Specifically, HMGA2-LM exhibited increased expression of VEGFA, EGF, bFGF, TGFα, VEGFR1, and VEGFR2 compared to MED12-LM and myometrium. reported no difference in the phenotype of benign tumors developed in transgenic mice expressing either a full-length or a truncated HMGA2 transcript under the control of a differentiated adipocyte-specific promoter. Cancer Res. 2008 Jan 23; PMID: 18214854, Rabban JT, Dal Cin P, Oliva E. HMGA2 rearrangement in a case of vulvar aggressive angiomyxoma. The non-histone chromatin-binding protein HMGA2 is expressed predominantly in the mesenchyme before its differentiation, but it is also expressed in tumors of epithelial origin. This website is intended for pathologists and laboratory personnel but not for patients. Gynecol Oncol. have demonstrated the amplification of exons 1-2 of HMGA2 in all the 38 WDLPS/DDLPS cases studied, against the nonconsistent amplification of exons 3-5. Bethesda, MD 20894, Copyright Fusion transcripts involving HMGA2 are not a common molecular mechanism in uterine leiomyomata with rearrangements in 12q15. Am J Surg Pathol. Ancillary Studies Cytogenetics. 48 talking about this. Keywords: Int J Cancer. Prevention and treatment information (HHS). HMGA2 gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family (HMGs). 572 talking about this. Myometrial cells with stable HMGA2 overexpression exhibited increased colony formation and cell growth in vitro and formed xenografts with increased blood vessels. The staining intensity of HMGA1 and HMGA2 is also significantly higher in adenocarcinomas than in adenomas or reactive atypias. MED12 and HMGA2 mutations: two independent genetic events in uterine leiomyoma and leiomyosarcoma. This fusion usually contains exons 1 to 3 of HMGA2 and exons 9 to 11 of LLP. 2011 Jun;20(2):71-80. Genes Chromosomes Cancer. In addition, extragenic breakpoints located 5 or 3 to HMGA2 similar to the rearrangements observed in uterine leiomyomas also occur in lipomas. HMGA2 expression is a highly specific (96.2%), but low-sensitivity (29.8%), marker for PA and CA ex-PA when compared with histological mimics, and is frequently associated with rearrangement of the HMGA2 … Zaidi et al. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. Among them, 93.9%(125/133) of mutations were confined to … Site Map However, cooperation between HMGA2 and CDK4, when amplified, may also play an important role. Interventions: Careers. 2014 Aug;27(8):1144-53. doi: 10.1038/modpathol.2013.243. In addition, HMGA2 overexpression could also result from the disruption of the 3UTR causing the loss of function of let-7, a microRNA specifically involved in the posttranscriptional repression of HMGA2. This site needs JavaScript to work properly. HMGA2 overexpression upregulated IGF2BP2 and pAKT, and silencing the IGF2BP2 gene reduced pAKT levels and reduced HUVEC migration. None. Rearrangement and overexpression of HMGA2 are observed in lipomas and in other benign tumors such as uterine leiomyomas and salivary gland pleomorphic adenomas. Epub 2014 Aug 5. Setting: Epub 2017 Oct 20. Expression was strong and diffuse throughout all PAs, and in four of nine positive CA ex‐PAs. It's expression is associated with neuronal, glial or neuroendocrine differentiation. Some results identifying variability in the dysregulation pattern of HMGA2 in WDLPS/DDLPS, strongly suggest that a misexpression of HMGA2, whatever the mechanism, might be sufficient for tumorigenesis. Epithelial–mesenchymal transition (EMT) is an important process during embryogenesis. The Pathology Atlas contains mRNA and protein expression data from 17 different forms of human cancer, as well as correlation analysis of mRNA expression and patient survival. High-mobility group AT-hook 2 (HMGA2) is an architectural transcription factor that plays essential roles in embryonic development and cancer progression.  salivary gland pleomorphic adenoma 2009 Oct 28. Twenty-five percent (8/32) of leiomyosarcomas had HMGA2 overexpression, and no MED12 mutations were found in HMGA2 positive leiomyosarcoma. Pathology Outlines Job Search. 2006 Oct;25(4):403-7. 2018 Sep;150(3):562-568. doi: 10.1016/j.ygyno.2018.07.007. / Ph.D. or Ph.D. (or equivalent) Assistant / Associate Professor of Clinical Pathology.Training in pathology, infectious diseases or medical Microbiology with experience in Molecular and clinical microbiology is required. HMGA2 expression is associated with cellular transformation (Berlingieri et al., 1995), directly correlates with the level of malignancy, and is linked to enhanced metastatic potential and poor clinical outcome in different cancers (Morishita et al., 2013; Sgarra et al., 2018). HMGA2 gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family (HMGs). (5)Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA. PLAG1 or HMGA2 rearrangements were identified in 6 (67%) of 9 hypocellular myxoid PAs and in 2 (29%) of 7 cellular PAs. Stains & molecular markers - HGAL. 2013 Apr;62(5):778-87. doi : 10.1111/his.12084 PMID: 23530587, HMGA2 expression analysis in cytological and paraffin-embedded tissue specimens of thyroid tumors by relative quantitative RT-PCR. The protein expression data is derived from antibody-based protein profiling using … The high mobility group A (HMGA2) gene encodes a protein that alters chromatin structure and regulates the transcription of many genes; it is implicated in both benign and malignant neoplasias, but its rearrangements are a feature of development of several mesenchymal tumors. High expression of high mobility group protein A2 (HMGA2) is correlated with the invasiveness of gastric cancer and is an independent prognostic factor. FOIA HMGA2 expression was identified in 19 PAs (33.9%) and nine CA ex‐PAs (24.3%). The role of angiogenic factors in fibroid pathogenesis: potential implications for future therapy. 3'RNA Sequencing Accurately Classifies Formalin-Fixed Paraffin-Embedded Uterine Leiomyomas. Epub 2013 Sep 29. Thank you for joining our Facebook page. This study involved evaluation of vessel density and angiogenic factors in leiomyomas with HMGA2 overexpression; examining angiogenic factor expression and AKT signaling in myometrial (MM) and leiomyoma cells by introducing HMGA2 overexpression in vitro; and exploring vessel formation induced by HMGA2 overexpression both in vitro and in vivo. PMID: 12021922, Berner JM, Meza-Zepeda LA, Kools PF, Forus A, Schoenmakers EF, Van de Ven WJ, Fodstad O, Myklebost O. HMGIC, the gene for an architectural transcription factor, is amplified and rearranged in a subset of human sarcomas. PMID: 14612541, Quade BJ, Weremowicz S, Neskey DM, Vanni R, Ladd C, Dal Cin P, Morton CC. HMGA2 plays an important role in angiogenesis and the involvement of IGF2BP2-mediated pAKT activity in angiogenesis, which provides a potential novel target for therapy for this subtype of LM. Mod Pathol. Inflammatory myofibroblastic tumor with HMGIC rearrangement.
hmga2 pathology outlines 2021